The “first” maternal effect gene
نویسندگان
چکیده
منابع مشابه
Basonuclin: a novel mammalian maternal-effect gene.
Basonuclin is a zinc-finger protein found in abundance in oocytes. It qualifies as a maternal-effect gene because the source of pre-implantation embryonic basonuclin is maternal. Using a transgenic-RNAi approach, we knocked down basonuclin specifically in mouse oocytes, which led to female sub-fertility. Basonuclin deficiency in oocytes perturbed both RNA polymerase I- and II-mediated transcrip...
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STUDY QUESTION Are maternal progesterone levels in early pregnancy associated with fetal birthweight? SUMMARY ANSWER Low levels of first-trimester maternal progesterone are significantly associated with a reduction in birthweight in girls, but not boys. WHAT IS ALREADY KNOWN Progesterone in the third trimester of pregnancy has previously been related to birthweight in humans. STUDY DESIGN...
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ژورنال
عنوان ژورنال: Molecular Reproduction and Development
سال: 2012
ISSN: 1040-452X
DOI: 10.1002/mrd.22116